AIScienceTechnology

RNA Structural Barriers Enhance CRISPR-Cas13 Diagnostic Precision and Mismatch Detection

Scientists have uncovered how RNA structural elements compete with CRISPR-Cas13 targeting, leading to a novel strand displacement model that explains Cas13 activation dynamics. The findings enable unprecedented specificity in detecting viral variants and single-nucleotide mutations, potentially revolutionizing molecular diagnostics.

RNA Structure Governs Cas13 Activation and Diagnostic Specificity

Recent research published in Nature Biotechnology reveals how RNA secondary structure fundamentally influences CRISPR-Cas13 activity, with significant implications for diagnostic applications. According to the report, RNA molecules form intramolecular base pairs that compete with the guide RNA (crRNA) for target binding, creating what sources describe as a “structural barrier” that modulates Cas13 activation.

BusinessInnovationTechnology

Visa Q4 Earnings Preview: Analysts Eye Strong Growth in Payment Volumes and Value-Added Services

Visa is set to announce its Q4 FY’25 earnings around October 28, 2025, with analysts forecasting significant revenue growth. The company’s performance is reportedly being fueled by robust payment volumes and expanding value-added services, including AI-powered fraud detection solutions. Market watchers are closely monitoring how these results might impact stock movement following the earnings release.

Visa’s Upcoming Earnings Report: What to Expect

Visa Inc. (NYSE:V) is reportedly preparing to announce its fourth-quarter fiscal year 2025 earnings on or around Tuesday, October 28, 2025, according to financial analysts. The payments giant is expected to demonstrate continued strength in its core business operations, with sources indicating approximately 10% year-over-year revenue growth to $10.6 billion. Earnings per share are estimated to reach $2.97 based on consensus forecasts.