HealthcareMedical

Dual-Drug Strategy Overcomes Resistance in Aggressive Leukemia Treatment

Scientists have identified why acute myeloid leukemia resists proteasome inhibitors that work well in multiple myeloma. By combining these drugs with autophagy blockers, researchers effectively killed AML cells and extended survival in models, offering hope for broader patient benefit regardless of genetic mutations.

Breakthrough in Leukemia Treatment Resistance

Researchers have uncovered the mechanism behind acute myeloid leukemia’s resistance to a class of drugs effective against other blood cancers, according to a new study from UC San Diego School of Medicine. The findings, published in Blood journal, reveal how AML cells activate backup systems to survive proteasome inhibitor treatment, which has long frustrated attempts to expand use of these medications beyond multiple myeloma.

Gaming

Halo Infinite Adds Classic Needler as Franchise Approaches 25th Anniversary Milestone

Halo Infinite is welcoming back the iconic Type-35 Needler from the original Halo: Combat Evolved as the franchise prepares for its 25th anniversary. Multiple reports indicate additional major announcements could be coming, including a potential remake and new live-service title. The developments signal Microsoft’s renewed commitment to the beloved Halo franchise during this milestone year.

Classic Weapon Returns for Anniversary Celebration

As the Halo franchise approaches its 25th anniversary next year, Halo Infinite is paying homage to its roots by introducing the Type-35 Needler from the original Halo: Combat Evolved. According to reports, this specific model represents a more advanced version of the weapon that first appeared in the 2001 game that launched the iconic series.